Journal Club

Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Traffic

Dev Cell, Volume 56, ISSUE 3, P341-355.e5, 2021

Highlights

• Disrupting FIP200 autophagy function abolishes HER2-driven mammary tumorigenesis

• Autophagy blockade reduces HER2 levels on tumor cell surfaces and tumorigenicity

• Autophagy inhibition diverts HER2 trafficking from the Golgi to endosomes and MVBs

• HER2 loss via sEVs decreases its level and tumorgenicity in autophagy-defective cells