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Journal Club
- nbidere
- 18 oct. 2021
- 1 min de lecture
Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Traffic
Dev Cell, Volume 56, ISSUE 3, P341-355.e5, 2021
Highlights
Disrupting FIP200 autophagy function abolishes HER2-driven mammary tumorigenesis
Autophagy blockade reduces HER2 levels on tumor cell surfaces and tumorigenicity
Autophagy inhibition diverts HER2 trafficking from the Golgi to endosomes and MVBs
HER2 loss via sEVs decreases its level and tumorgenicity in autophagy-defective cells
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