Journal Club

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

Cell VOLUME 184, ISSUE 17, P4495-4511.E19, AUGUST 19, 2021

Highlights

• The Ragulator-Rag-mTORC1 pathway is required for pyroptosis induced by gasdermin D

• Ragulator-Rag promotes gasdermin D oligomerization but not membrane localization

• Ragulator-Rag promotes reactive oxygen species (ROS) production in macrophages

• ROS promotes gasdermin D oligomerization, pore formation, and pyroptosis