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Journal Club

  • nbidere
  • 8 nov. 2021
  • 1 min de lecture

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

Cell VOLUME 184, ISSUE 17, P4495-4511.E19, AUGUST 19, 2021



Highlights


  • The Ragulator-Rag-mTORC1 pathway is required for pyroptosis induced by gasdermin D


  • Ragulator-Rag promotes gasdermin D oligomerization but not membrane localization


  • Ragulator-Rag promotes reactive oxygen species (ROS) production in macrophages


  • ROS promotes gasdermin D oligomerization, pore formation, and pyroptosis



 
 
 

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