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Journal Club
- nbidere
- 22 nov. 2021
- 1 min de lecture
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion
Cell 2021 Sep 30;184(20):5230-5246.e22.
Highlights
• Deformed nuclei and DNA damage are enriched at micro-invasive foci of breast cancer
• TREX1 causes DNA damage in deformed nuclei upon nuclear envelope rupture events
• TREX1 drives senescence in normal cells and an invasive phenotype in cancer cells
• Nuclear envelope rupture events and DNA damage are observed in human tumors
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