Journal Club

Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

Cell 2021 Sep 30;184(20):5230-5246.e22.

Highlights

• Deformed nuclei and DNA damage are enriched at micro-invasive foci of breast cancer

• TREX1 causes DNA damage in deformed nuclei upon nuclear envelope rupture events

• TREX1 drives senescence in normal cells and an invasive phenotype in cancer cells

• Nuclear envelope rupture events and DNA damage are observed in human tumors