Journal Club

E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

Highlights • RNF167 and STAMBPL1 modulate Sestrin2 ubiquitination in response to leucine status

• Ubiquitinated Sestrin2 inhibits mTORC1 activity by sequestering GATOR2

• Suppression of STAMBPL1 function inhibits tumor growth

• STAMBPL1 is a potential therapeutic target in colorectal cancer