Rechercher
Journal Club
- nbidere
- 21 févr. 2022
- 1 min de lecture
E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
Highlights • RNF167 and STAMBPL1 modulate Sestrin2 ubiquitination in response to leucine status
• Ubiquitinated Sestrin2 inhibits mTORC1 activity by sequestering GATOR2
• Suppression of STAMBPL1 function inhibits tumor growth
• STAMBPL1 is a potential therapeutic target in colorectal cancer
Opmerkingen