Journal Club

The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation

Molecular Cell, Volume 82, Issue 5, 3 March 2022, Pages 933-949.e9

Highlights •BAK oligomerizes faster into smaller lines, arcs, and rings than those formed by BAX

•BAK recruits BAX to co-assemble into the same supra-molecular apoptotic structures

•BAX and BAK reciprocal regulation defines the growth dynamics of apoptotic pores

•BAX and BAK have distinct roles in modulating the inflammatory outcome of apoptosis