Journal Club

Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy

Cancer Cell Volume 40, Issue 3, 14 March 2022, Pages 318-334.e9

Highlights • TA-HEVs are main sites of lymphocyte extravasation into αPD-1/αCTLA-4-treated tumors

• TA-HEV endothelial cells (TA-HECs) have a unique bifunctional hybrid phenotype

• Increasing TA-HEC differentiation increases the proportion of stem-like CD8+ T cells

• TA-HEVs predict response and survival of melanoma patients treated with αPD-1/αCTLA-4