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Journal Club
- nbidere
- 19 avr. 2022
- 1 min de lecture
Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
Cancer Cell Volume 40, Issue 3, 14 March 2022, Pages 318-334.e9
Highlights • TA-HEVs are main sites of lymphocyte extravasation into αPD-1/αCTLA-4-treated tumors
• TA-HEV endothelial cells (TA-HECs) have a unique bifunctional hybrid phenotype
• Increasing TA-HEC differentiation increases the proportion of stem-like CD8+ T cells
• TA-HEVs predict response and survival of melanoma patients treated with αPD-1/αCTLA-4
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