Rechercher
Journal Club
- nbidere
- 25 avr. 2022
- 1 min de lecture
YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
Developmental Cell Volume 57, Issue 6, 28 March 2022, Pages 719-731.e8
Highlights
•YAP co-opts the mTORC1/SREBP pathway to activate lipogenesis
•Crosstalk between YAP and mTORC1 is mediated by the YAP/TEAD target gene SGK1
•YAP-driven lipogenesis is dependent on SGK1 and independent of AKT
•Inhibition of lipogenesis suppresses YAP-dependent proliferation and tissue growth
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