Journal Club

YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth

Developmental Cell Volume 57, Issue 6, 28 March 2022, Pages 719-731.e8

Highlights

•YAP co-opts the mTORC1/SREBP pathway to activate lipogenesis

•Crosstalk between YAP and mTORC1 is mediated by the YAP/TEAD target gene SGK1

•YAP-driven lipogenesis is dependent on SGK1 and independent of AKT

•Inhibition of lipogenesis suppresses YAP-dependent proliferation and tissue growth