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Journal Club
- nbidere
- 22 févr. 2021
- 1 min de lecture
Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit
Cell Stem Cell Volume 26, Issue 4, 2 April 2020, Pages 558-568.e9
Highlights • Mammalian NSCs utilize vimentin-caged aggresomes to recover proteostasis
• Vimentin is required for proteasome localization to the aggresome in NSCs
• Quiescent NSCs upregulate vimentin protein and utilize aggresomes during activation
• Vimentin knockout in NSCs impairs proteostasis recovery and delays quiescence exit
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