Journal Club

Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit

Cell Stem Cell Volume 26, Issue 4, 2 April 2020, Pages 558-568.e9

Highlights • Mammalian NSCs utilize vimentin-caged aggresomes to recover proteostasis

• Vimentin is required for proteasome localization to the aggresome in NSCs

• Quiescent NSCs upregulate vimentin protein and utilize aggresomes during activation

• Vimentin knockout in NSCs impairs proteostasis recovery and delays quiescence exit