Journal Club

Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB

Mol Cell 2022, in press

Highlights

• NEMO binding to polyubiquitin chains leads to the formation of liquid droplets

• Multivalent interactions between NEMO and polyubiquitin drive their phase condensation

• IKK is activated within the NEMO condensates

• Human disease-associated mutations of NEMO impair phase separation and IKK activation