Rechercher
Journal Club
- nbidere
- 13 juin 2022
- 1 min de lecture
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB
Mol Cell 2022, in press
Highlights
• NEMO binding to polyubiquitin chains leads to the formation of liquid droplets
• Multivalent interactions between NEMO and polyubiquitin drive their phase condensation
• IKK is activated within the NEMO condensates
• Human disease-associated mutations of NEMO impair phase separation and IKK activation
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