Journal Club

Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion

Dev Cell Volume 56, Issue 20, 25 October 2021, Pages 2841-2855.e8

Highlights • GBM invasive strength is due to diverse motility modes unveiled by micropatterns

• GBM mechanical cohesion adjusts cell forces, leading to motility and invasiveness

• The formin FMN1 regulates GBM mechanics from the microtubule lattice

• FMN1 expression is tuned mechanically and chemically by the substrate