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Rechercher

Journal Club

  • nbidere
  • 20 juin 2022
  • 1 min de lecture

Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion


Dev Cell Volume 56, Issue 20, 25 October 2021, Pages 2841-2855.e8





Highlights • GBM invasive strength is due to diverse motility modes unveiled by micropatterns


• GBM mechanical cohesion adjusts cell forces, leading to motility and invasiveness


• The formin FMN1 regulates GBM mechanics from the microtubule lattice


• FMN1 expression is tuned mechanically and chemically by the substrate

 
 
 

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