Journal Club

Neuroinflammatory disease disrupts the blood-CNS barrier via crosstalk between proinflammatory and endothelial-to-mesenchymal-transition signaling

Neuron, Aug 2022

Highlights • EndoMT occurs in the CNS before the onset of symptoms in a mouse model of MS

• EndoMT helps drive the loss of BCNSB function and is induced by ARF6 activation

• ARF6 activation mediates crosstalk between IL-1β and ALK-SMAD1/5 signaling pathways

• Inhibiting the IL-1β-ARF6-ALK-SMAD1/5 pathway reverses EndoMT and disease severity