Journal Club

Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis

Cell 2022 Volume 185, ISSUE 17, P3214-3231.e23

Highlights

• Altered mitochondrial homeostasis reprograms cell death modalities

• Mitochondrial ROS directs GSDMD to mitochondria following inflammasome activation

• Mito-GSDMD shifts cell death from pyroptosis to necroptosis in Lrrk2G2019S macrophages

• Lrrk2G2019S elicits hyperinflammation and susceptibility to infection in flies and mice