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Rechercher

Journal Club

  • nbidere
  • 10 oct. 2022
  • 1 min de lecture

Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis


Cell 2022 Volume 185, ISSUE 17, P3214-3231.e23




Highlights


  • Altered mitochondrial homeostasis reprograms cell death modalities


  • Mitochondrial ROS directs GSDMD to mitochondria following inflammasome activation


  • Mito-GSDMD shifts cell death from pyroptosis to necroptosis in Lrrk2G2019S macrophages


  • Lrrk2G2019S elicits hyperinflammation and susceptibility to infection in flies and mice


 
 
 

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