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Journal Club
- nbidere
- 5 déc. 2022
- 1 min de lecture
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling
Cell Stem Cell, Volume 29, Issue 11, 3 November 2022, Pages 1509-1510
Highlights
• Histamine synthesis and secretion are enhanced in GSCs
• Epigenetic activation of HDC drives GSC to secrete histamine
• GSC-secreted histamine promotes glioblastoma progression by increasing angiogenesis
• Pharmacological inhibition of GSC-secreted histamine impedes GBM progression
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