Journal Club

Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling

Cell Stem Cell, Volume 29, Issue 11, 3 November 2022, Pages 1509-1510

Highlights

• Histamine synthesis and secretion are enhanced in GSCs

• Epigenetic activation of HDC drives GSC to secrete histamine

• GSC-secreted histamine promotes glioblastoma progression by increasing angiogenesis

• Pharmacological inhibition of GSC-secreted histamine impedes GBM progression