Rechercher
Journal Club
- nbidere
- 9 janv. 2023
- 1 min de lecture
Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells
Cell Metabolism Volume 34, ISSUE 12, P1960-1976.e9, December 06, 2022
Highlights
Lung mesenchymal cells (MCs) store neutral lipids during breast cancer progression
IL-1β elicits neutral lipid accumulation in lung MCs to foster metastas
Lipid-laden MCs metabolically reprogram both tumor cells and NK cells
Targeting lipid-laden MCs improves the efficacy of NK cell-based immunotherapy
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