Journal Club

Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

Cell Metabolism Volume 34, ISSUE 12, P1960-1976.e9, December 06, 2022

Highlights

• Lung mesenchymal cells (MCs) store neutral lipids during breast cancer progression

• IL-1β elicits neutral lipid accumulation in lung MCs to foster metastas

• Lipid-laden MCs metabolically reprogram both tumor cells and NK cells

• Targeting lipid-laden MCs improves the efficacy of NK cell-based immunotherapy