Rechercher
Journal Club
- nbidere
- 6 mars 2023
- 1 min de lecture
Cationic amphiphilic antihistamines inhibit STAT3 via Ca2+-dependent lysosomal H+ efflux
Cell Reports Volume 42, ISSUE 2, 112137, February 28, 2023
Highlights
CADs trigger lysosomal H+ efflux and cytosolic acidification
CADs are effective STAT3 inhibitors
CADs sensitize cancer cells to apoptosis induced by STAT3 inhibition
CADs and STAT3 inhibitor WP1066 show synergistic anticancer activity in vivo
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