Journal Club

Cationic amphiphilic antihistamines inhibit STAT3 via Ca2+-dependent lysosomal H+ efflux

Cell Reports Volume 42, ISSUE 2, 112137, February 28, 2023

Highlights

• CADs trigger lysosomal H+ efflux and cytosolic acidification

• CADs are effective STAT3 inhibitors

• CADs sensitize cancer cells to apoptosis induced by STAT3 inhibition

• CADs and STAT3 inhibitor WP1066 show synergistic anticancer activity in vivo