Journal Club

Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy

Cell Reports Volume 42, ISSUE 10, 113138, October 31, 2023

Highlights

• Bispecific EVs expressing aCD19 and PD1 are developed by genetic engineering

• Bispecific EVs target tumor antigen huCD19 and bind PD-L1 within solid tumors

• Bispecific EVs also target tumor-derived EVs to prevent the formation of premetastatic niche