Journal Club

Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment

Dev Cell Volume 55, Issue 2, 26 October 2020, Pages 163-177.e6

Highlights • Hypoxic breast cancer cells release signaling sEVs

• sEVs activate mitochondrial dynamics in recipient normal mammary epithelium

• Mitochondrial reprogramming stimulates ILK-Akt-dependent epithelial cell migration

• sEVs disrupt normal mammary gland morphogenesis with hallmarks of malignancy