Rechercher
Journal Club
- nbidere
- 23 mars 2021
- 1 min de lecture
Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment
Dev Cell Volume 55, Issue 2, 26 October 2020, Pages 163-177.e6
Highlights • Hypoxic breast cancer cells release signaling sEVs
• sEVs activate mitochondrial dynamics in recipient normal mammary epithelium
• Mitochondrial reprogramming stimulates ILK-Akt-dependent epithelial cell migration
• sEVs disrupt normal mammary gland morphogenesis with hallmarks of malignancy
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