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Journal Club

Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity


Cell Reports Volume 42, Issue 10, 31 October 2023, 113224




Highlights

  • Tumor-associated macrophages secrete a large amount of PD-L1+ small extracellular vesicles


  • Akt promotes exosome secretion in TAMs through MADD phosphorylation


  • TAM-derived exosomes inhibit CD8 T cell proliferation and function


  • Targeting macrophage RAB27A by LNPs sensitizes tumor to anti-PD-1 antibody


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