Journal Club

Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity

Cell Reports Volume 42, Issue 10, 31 October 2023, 113224

Highlights

• Tumor-associated macrophages secrete a large amount of PD-L1+ small extracellular vesicles

• Akt promotes exosome secretion in TAMs through MADD phosphorylation

• TAM-derived exosomes inhibit CD8 T cell proliferation and function

• Targeting macrophage RAB27A by LNPs sensitizes tumor to anti-PD-1 antibody