Journal Club:Cell Lineage-Based Stratification for Glioblastoma

Cancer Cell 2020

Highlights • Tumor suppressor loss in NSCs and OLCs generate distinct murine GBM subtypes

• Human GBM subtypes identified based on species-conserved transcriptional profiles

• Mouse and human cell lineage subtypes exhibit distinct tumor properties

• OLC-associated GBMs show ERBB3 dependence and unique therapeutic sensitivity