Journal Club:Cell Lineage-Based Stratification for Glioblastoma
- nbidere
- 24 nov. 2020
- 1 min de lecture
Cancer Cell 2020
Highlights • Tumor suppressor loss in NSCs and OLCs generate distinct murine GBM subtypes
• Human GBM subtypes identified based on species-conserved transcriptional profiles
• Mouse and human cell lineage subtypes exhibit distinct tumor properties
• OLC-associated GBMs show ERBB3 dependence and unique therapeutic sensitivity
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