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Journal Club: RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
- nbidere
- 6 avr. 2021
- 1 min de lecture
Molecular Cell, Volume 81, ISSUE 2, P370-385.e7, January 21, 2021
Highlights
RIPK1 loss results in elevated mTORC1 activity, causing lysosomal dysfunction
RIPK1 regulates mTORC1 inhibition by AMPK
RIPK1 acts as a scaffold to promote TSC2 phosphorylation by AMPK at Ser1387
mTORC1 inhibitor rapamycin prolongs survival of RIPK1 knockout newborn mice
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