Journal Club: RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

Molecular Cell, Volume 81, ISSUE 2, P370-385.e7, January 21, 2021

Highlights

• RIPK1 loss results in elevated mTORC1 activity, causing lysosomal dysfunction

• RIPK1 regulates mTORC1 inhibition by AMPK

• RIPK1 acts as a scaffold to promote TSC2 phosphorylation by AMPK at Ser1387

• mTORC1 inhibitor rapamycin prolongs survival of RIPK1 knockout newborn mice