Journal Club: Taxanes trigger cancer cell killing in vivo by inducing non-canonical T cell cytotoxic

Cancer Cell:

Volume 41, ISSUE 6, P1170-1185.e12, June 12, 2023

Highlights

• T cells mediate taxane cytotoxicity in vivo

• Taxanes trigger T cells to release cytotoxic extracellular vesicles

• Taxanes increase TCR-independent and TCR-mediated T cell killing

• T cells treated ex vivo with taxanes can eradicate tumors in vivo