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Journal Club: β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway
- nbidere
- 16 nov. 2020
- 1 min de lecture
Cell 2020
Highlights • β-Coronaviruses do not use the biosynthetic secretory pathway to egress
• β-Coronaviruses traffic to lysosomes and egress by Arl8b-dependent lysosomal exocytosis
• Lysosomes are deacidified, and proteolytic enzymes are inactive in infected cells
• Antigen processing and presentation are perturbed in β-coronavirus infection
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