Serine 165 Phosphorylation of SHARPIN regulates the Activation of NF-κB
- nbidere
- 14 déc. 2020
- 1 min de lecture
Thys et al., iScience 2020
Highlights
Part of SHARPIN is constitutively phosphorylated on S165 in lymphoblastoid cells
SHARPIN S165 phosphorylation governs TNFα-mediated linear ubiquitination of NEMO
Mutation of S165 hinders NF-κB activation
Commentaires