Serine 165 Phosphorylation of SHARPIN regulates the Activation of NF-κB

Thys et al., iScience 2020

Highlights

• Part of SHARPIN is constitutively phosphorylated on S165 in lymphoblastoid cells

• SHARPIN S165 phosphorylation governs TNFα-mediated linear ubiquitination of NEMO

• Mutation of S165 hinders NF-κB activation