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Serine 165 Phosphorylation of SHARPIN regulates the Activation of NF-κB

  • nbidere
  • 14 déc. 2020
  • 1 min de lecture

Thys et al., iScience 2020






Highlights

  • Part of SHARPIN is constitutively phosphorylated on S165 in lymphoblastoid cells

  • SHARPIN S165 phosphorylation governs TNFα-mediated linear ubiquitination of NEMO

  • Mutation of S165 hinders NF-κB activation


 
 
 

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