Signaling in Oncogenesis, Angiogenesis, and Permeability

Although the aetiology of amyotrophic lateral sclerosis (ALS) remains poorly understood, impaired proteostasis is a common feature of...

We are happy to welcome two highschool students Louis & Valentine for 1-week immersion day in the lab :-) We are pleased to welcome...

Abstract Tumor cells evade the immune surveillance by up-regulating surface expression of PD-L1, which interacts with PD-1 on T cells to...

Highlights TNFα induces the recruitment of MST1 to the TNFR1 signaling complex (TNF-RSC) TRAF2 is required for the TNFα-induced...

Pre-prints are amazing!!! https://www.biorxiv.org/content/10.1101/582221v1.article-metrics

Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self DNA in the cytoplasm1. Upon...

The presence of disseminated tumour cells (DTCs) in bone marrow is predictive of poor metastasis-free survival of patients with breast...

Highlights LPS treatment causes a decrease in HBP activity and protein O-GlcNAcylation OGT deficiency increases activation of innate...

Highlights Pacer is a regulator of hepatic autophagy and liver homeostasis Pacer is directly phosphorylated by mTORC1 under nutrient-rich...