Signaling in Oncogenesis, Angiogenesis, and Permeability

Highlights Pacer is a regulator of hepatic autophagy and liver homeostasis Pacer is directly phosphorylated by mTORC1 under nutrient-rich...

First Pre-Print of the Lab !! doi: https://doi.org/10.1101/537753

Abstract: Exosomes, a type of small extracellular vesicles (sEVs), derived from multivesicular bodies (MVBs), mediate cell-to-cell...

The increasing prevalence of diabetes has resulted in a global epidemic1. Diabetes is a major cause of blindness, kidney failure, heart...

The linear ubiquitin chain assembly complex (LUBAC), composed of HOIP, HOIL-1 and SHARPIN, is required for optimal TNF-mediated gene...

Early invasive growth along specific anatomical structures, especially the white matter tract, is regarded as one of the main causes of...

Maintaining innate immune homeostasis is important for individual health. Npl4 zinc finger (NZF) domain-mediated ubiquitin chain sensing...

he NLRP3 inflammasome, which has been linked to human inflammatory diseases, is activated by diverse stimuli. How these stimuli activate...

Dysregulated intracellular pH is emerging as a hallmark of cancer. In spite of their acidic environment and increased acid production,...