Signaling in Oncogenesis, Angiogenesis, and Permeability

Early invasive growth along specific anatomical structures, especially the white matter tract, is regarded as one of the main causes of...

Maintaining innate immune homeostasis is important for individual health. Npl4 zinc finger (NZF) domain-mediated ubiquitin chain sensing...

he NLRP3 inflammasome, which has been linked to human inflammatory diseases, is activated by diverse stimuli. How these stimuli activate...

Dysregulated intracellular pH is emerging as a hallmark of cancer. In spite of their acidic environment and increased acid production,...

The linear-ubiquitin chain assembly complex (LUBAC) modulates signalling via various immune receptors. In tumour necrosis factor (TNF)...

Highlights MLKL expression is induced in the Schwann cells of sciatic nerves following injury MLKL is phosphorylated at serine 441 site...

Differentiated tumor cells cooperate with glioma stem cells to promote tumor growth Differentiated glioma cells secrete BDNF to stimulate...

Abstract Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming fragment, which controls pyroptosis in...