Signaling in Oncogenesis, Angiogenesis, and Permeability

STAT3 is a transcription factor that plays central roles in various physiological processes and its deregulation results in serious...

A subset of CYLD is found at the centriolar satellites CYLD maintains the proteostasis of the centriolar satellites CYLD removes...

A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago1,2. The individual—who is known as the ‘Berlin...

Metabolic reprogramming is a hallmark of cancer. Here, we demonstrate that tumour-associated macrophages (TAMs) enhance the aerobic...

Notch signaling is a core patterning module for vascular morphogenesis that codetermines the sprouting behavior of endothelial cells...

The non-canonical NF-κB signalling cascade is essential for lymphoid organogenesis, B cell maturation, osteoclast differentiation, and...

Although the aetiology of amyotrophic lateral sclerosis (ALS) remains poorly understood, impaired proteostasis is a common feature of...

We are happy to welcome two highschool students Louis & Valentine for 1-week immersion day in the lab :-) We are pleased to welcome...

Abstract Tumor cells evade the immune surveillance by up-regulating surface expression of PD-L1, which interacts with PD-1 on T cells to...

Highlights TNFα induces the recruitment of MST1 to the TNFR1 signaling complex (TNF-RSC) TRAF2 is required for the TNFα-induced...