cancer research lab in Nantes

Journal Club: Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self DNA in the cytoplasm1. Upon...

Event: Gwennan to present at Canceropole - NET day

Journal Club: Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

The presence of disseminated tumour cells (DTCs) in bone marrow is predictive of poor metastasis-free survival of patients with breast...

Journal Club: O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Int

Highlights LPS treatment causes a decrease in HBP activity and protein O-GlcNAcylation OGT deficiency increases activation of innate...

Journal Club: Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome

Highlights Pacer is a regulator of hepatic autophagy and liver homeostasis Pacer is directly phosphorylated by mTORC1 under nutrient-rich...

Highlight: Pannexin-1 Channels govern the Generation of Necroptotic small Extracellular Vesicles

First Pre-Print of the Lab !! doi: https://doi.org/10.1101/537753

Journal Club: UBL3 modification influences protein sorting to small extracellular vesicles

Abstract: Exosomes, a type of small extracellular vesicles (sEVs), derived from multivesicular bodies (MVBs), mediate cell-to-cell...

Journal Club: Human blood vessel organoids as a model of diabetic vasculopathy

The increasing prevalence of diabetes has resulted in a global epidemic1. Diabetes is a major cause of blindness, kidney failure, heart...

Journal Club: LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD

The linear ubiquitin chain assembly complex (LUBAC), composed of HOIP, HOIL-1 and SHARPIN, is required for optimal TNF-mediated gene...

Journal Club: Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 pos

Early invasive growth along specific anatomical structures, especially the white matter tract, is regarded as one of the main causes of...