Highlight: Pannexin-1 Channels govern the Generation of Necroptotic small Extracellular Vesicles
First Pre-Print of the Lab !! doi: https://doi.org/10.1101/537753
Journal Club: UBL3 modification influences protein sorting to small extracellular vesicles
Abstract: Exosomes, a type of small extracellular vesicles (sEVs), derived from multivesicular bodies (MVBs), mediate cell-to-cell...
Journal Club: Human blood vessel organoids as a model of diabetic vasculopathy
The increasing prevalence of diabetes has resulted in a global epidemic1. Diabetes is a major cause of blindness, kidney failure, heart...
Journal Club: LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD
The linear ubiquitin chain assembly complex (LUBAC), composed of HOIP, HOIL-1 and SHARPIN, is required for optimal TNF-mediated gene...
Journal Club: Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 pos
Early invasive growth along specific anatomical structures, especially the white matter tract, is regarded as one of the main causes of...
Journal Club: Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing
Maintaining innate immune homeostasis is important for individual health. Npl4 zinc finger (NZF) domain-mediated ubiquitin chain sensing...
Journal Club: PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
he NLRP3 inflammasome, which has been linked to human inflammatory diseases, is activated by diverse stimuli. How these stimuli activate...
Journal Club: STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH
Dysregulated intracellular pH is emerging as a hallmark of cancer. In spite of their acidic environment and increased acid production,...
Journal Club: TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation
The linear-ubiquitin chain assembly complex (LUBAC) modulates signalling via various immune receptors. In tumour necrosis factor (TNF)...