Signaling in Oncogenesis, Angiogenesis, and Permeability

The linear-ubiquitin chain assembly complex (LUBAC) modulates signalling via various immune receptors. In tumour necrosis factor (TNF)...

Highlights MLKL expression is induced in the Schwann cells of sciatic nerves following injury MLKL is phosphorylated at serine 441 site...

Differentiated tumor cells cooperate with glioma stem cells to promote tumor growth Differentiated glioma cells secrete BDNF to stimulate...

Abstract Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming fragment, which controls pyroptosis in...

T cell dysfunction contributes to tumor immune escape in patients with cancer and is particularly severe amidst glioblastoma (GBM). Among...

Our review soon to be on-line! Piracy of the NF-kB transcription factors signaling pathway, to sustain its activity, is a mechanism often...

CRISPR–Cas-based genome editing holds great promise for targeting genetic disorders, including inborn errors of hepatocyte metabolism....

RAB11A binds WIPI2 via a conserved RAB11-binding domain and regulates autophagy Proteins regulating autophagosome formation localize on...