cancer research lab in Nantes

Journal Club: Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing

Maintaining innate immune homeostasis is important for individual health. Npl4 zinc finger (NZF) domain-mediated ubiquitin chain sensing...

Journal Club: PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

he NLRP3 inflammasome, which has been linked to human inflammatory diseases, is activated by diverse stimuli. How these stimuli activate...

Event: Mark your calendar !!! 2nd SOAPosium 14th December

Journal Club: STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH

Dysregulated intracellular pH is emerging as a hallmark of cancer. In spite of their acidic environment and increased acid production,...

Journal Club: TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

The linear-ubiquitin chain assembly complex (LUBAC) modulates signalling via various immune receptors. In tumour necrosis factor (TNF)...

Journal Club: Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injur

Highlights MLKL expression is induced in the Schwann cells of sciatic nerves following injury MLKL is phosphorylated at serine 441 site...

Event: Cinquième journée du theme scientifique signalisation et cancer (scan) de la sfr biosit de re

Journal Club: Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Pr

Differentiated tumor cells cooperate with glioma stem cells to promote tumor growth Differentiated glioma cells secrete BDNF to stimulate...

Journal Club: Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cel

Abstract Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming fragment, which controls pyroptosis in...

Journal Club: Sequestration of T cells in bone marrow in the setting of glioblastoma and other intra

T cell dysfunction contributes to tumor immune escape in patients with cancer and is particularly severe amidst glioblastoma (GBM). Among...