Journal Club: STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH
Dysregulated intracellular pH is emerging as a hallmark of cancer. In spite of their acidic environment and increased acid production,...
Journal Club: TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation
The linear-ubiquitin chain assembly complex (LUBAC) modulates signalling via various immune receptors. In tumour necrosis factor (TNF)...
Journal Club: Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injur
Highlights MLKL expression is induced in the Schwann cells of sciatic nerves following injury MLKL is phosphorylated at serine 441 site...
Journal Club: Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Pr
Differentiated tumor cells cooperate with glioma stem cells to promote tumor growth Differentiated glioma cells secrete BDNF to stimulate...
Journal Club: Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cel
Abstract Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming fragment, which controls pyroptosis in...
Journal Club: Sequestration of T cells in bone marrow in the setting of glioblastoma and other intra
T cell dysfunction contributes to tumor immune escape in patients with cancer and is particularly severe amidst glioblastoma (GBM). Among...
ResearchHighlight: Post-translational Modifications of the CARMA1-BCL10-MALT1 Complex in Lymphocytes
Our review soon to be on-line! Piracy of the NF-kB transcription factors signaling pathway, to sustain its activity, is a mechanism often...