cancer research lab in Nantes

Event: Welcome Fiorella!

Fiorella graduates from Universidad Austral, Buenos Aires, Argentina, where she explored the implications of hyaluronan and its chemical...

Journal Club: Decellularized extracellular matrix scaffolds identifyfull-length collagen VI...

Science Advances 21 Oct 2020 Abstract The extracellular matrix (ECM), a major component of the tumor microenvironment, promotes local...

Journal Club: Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression

Nature Communications volume 11, Article number: 5424 (2020) Abstract Tumor necrosis commonly exists and predicts poor prognoses in...

Journal Club: A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade

Mol Cell 2020 Summary Necroptosis induction in vitro often requires caspase-8 (Casp8) inhibition by zVAD because pro-Casp8 cleaves RIP1...

Journal Club: HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

The MTOC is “speck”-tacular Inflammasome complexes are formed in response to pathogen-associated molecules. They initiate both the...

Journal Club: Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Cell There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic...

Journal Club: NINJ1 mediates plasma membrane rupture during lytic cell death

#ResearchSquare #Preprints Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR releases intracellular...

Journal Club: Age-induced accumulation of methylmalonic acid promotes tumour progression

Nature volume 585, pages283–287(2020) Abstract The risk of cancer and associated mortality increases substantially in humans from the age...

Journal Club: The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exoc

Highlights Tissue acidification is a major chemical hallmark of the tumor microenvironment PRL-expressing cells can grow in an acidic...

Journal Club: Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth

Breast cancer brain metastases (BCBM) have a 5-20 year latency and account for 30% of mortality; however, mechanisms governing adaptation...