

Journal Club:Cell Lineage-Based Stratification for Glioblastoma
Cancer Cell 2020 Highlights • Tumor suppressor loss in NSCs and OLCs generate distinct murine GBM subtypes • Human GBM subtypes...


Event: Fondation ARC JJC2020
Follow the on-line event with An Thys, Katie Jacobs, and Sara Rosinska


Journal Club: β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway
Cell 2020 Highlights • β-Coronaviruses do not use the biosynthetic secretory pathway to egress • β-Coronaviruses traffic to lysosomes...


Journal Club: cAbl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder
iScience 2020 Summary The transcription factor EB (TFEB) has emerged as a master regulator of lysosomal biogenesis, exocytosis, and...


Event: Welcome Fiorella!
Fiorella graduates from Universidad Austral, Buenos Aires, Argentina, where she explored the implications of hyaluronan and its chemical...
Journal Club: Decellularized extracellular matrix scaffolds identifyfull-length collagen VI...
Science Advances 21 Oct 2020 Abstract The extracellular matrix (ECM), a major component of the tumor microenvironment, promotes local...
Journal Club: Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
Nature Communications volume 11, Article number: 5424 (2020) Abstract Tumor necrosis commonly exists and predicts poor prognoses in...


Journal Club: A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade
Mol Cell 2020 Summary Necroptosis induction in vitro often requires caspase-8 (Casp8) inhibition by zVAD because pro-Casp8 cleaves RIP1...


Journal Club: HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
The MTOC is “speck”-tacular Inflammasome complexes are formed in response to pathogen-associated molecules. They initiate both the...