Signaling in Oncogenesis, Angiogenesis, and Permeability

iScience 2020 Summary The transcription factor EB (TFEB) has emerged as a master regulator of lysosomal biogenesis, exocytosis, and...

Fiorella graduates from Universidad Austral, Buenos Aires, Argentina, where she explored the implications of hyaluronan and its chemical...

Science Advances  21 Oct 2020 Abstract The extracellular matrix (ECM), a major component of the tumor microenvironment, promotes local...

Nature Communications volume 11, Article number: 5424 (2020) Abstract Tumor necrosis commonly exists and predicts poor prognoses in...

Mol Cell 2020 Summary Necroptosis induction in vitro often requires caspase-8 (Casp8) inhibition by zVAD because pro-Casp8 cleaves RIP1...

The MTOC is “speck”-tacular Inflammasome complexes are formed in response to pathogen-associated molecules. They initiate both the...

Cell There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic...

#ResearchSquare #Preprints Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR releases intracellular...

Nature volume 585, pages283–287(2020) Abstract The risk of cancer and associated mortality increases substantially in humans from the age...

Highlights Tissue acidification is a major chemical hallmark of the tumor microenvironment PRL-expressing cells can grow in an acidic...