Signaling in Oncogenesis, Angiogenesis, and Permeability

The pro-survival function of OTULIN is regulated by post-translational modifications OTULIN sustains CYLD activity by preventing its...

Summary Endomembrane damage elicits homeostatic responses including ESCRT-dependent membrane repair and autophagic removal of damaged...

Exploring drug repurposing to treat glioblastoma Dr. Tilmann Kiessling EMBO Communications EMBO - excellence in life sciences MALT1...

Abstract Glioblastoma is one of the most lethal forms of adult cancer with a median survival of around 15 months. A potential treatment...

An Thys received Helen Starck award from Fondation ARC for her work on Sharpin! Well deserved :-)

Self–non-self discrimination is central to T cell-mediated immunity. The kinetic proofreading model can explain T cell antigen receptor...

Abstract Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids. To date, ferroptosis...

Highlights • DRAM-1 is required for efficient activation of the nutrient-sensing complex mTORC1 • DRAM-1 and SCAMP3 direct newly...