cancer research lab in Nantes

Highlight: CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1

A subset of CYLD is found at the centriolar satellites CYLD maintains the proteostasis of the centriolar satellites CYLD removes...

Journal Club: HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago1,2. The individual—who is known as the ‘Berlin...

Journal Club: Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrop

Metabolic reprogramming is a hallmark of cancer. Here, we demonstrate that tumour-associated macrophages (TAMs) enhance the aerobic...

Journal Club: Deubiquitinase USP10 regulates Notch signaling in the endothelium

Notch signaling is a core patterning module for vascular morphogenesis that codetermines the sprouting behavior of endothelial cells...

Journal Club: A NIK–SIX signalling axis controls inflammation by targeted silencing of non-canonical

The non-canonical NF-κB signalling cascade is essential for lymphoid organogenesis, B cell maturation, osteoclast differentiation, and...

Journal Club: Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidificatio

Although the aetiology of amyotrophic lateral sclerosis (ALS) remains poorly understood, impaired proteostasis is a common feature of...

Event: welcome day @LabSoap

We are happy to welcome two highschool students Louis & Valentine for 1-week immersion day in the lab :-) We are pleased to welcome...

Journal Club: Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Respo

Abstract Tumor cells evade the immune surveillance by up-regulating surface expression of PD-L1, which interacts with PD-1 on T cells to...

Journal Club: MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activi

Highlights TNFα induces the recruitment of MST1 to the TNFR1 signaling complex (TNF-RSC) TRAF2 is required for the TNFα-induced...

Highlight: Control of the Endo-Lysosome Homeostasis by the Paracaspase MALT1 regulates Glioma Cell S

Pre-prints are amazing!!! https://www.biorxiv.org/content/10.1101/582221v1.article-metrics