Journal Club: Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus i
Gastrointestinal stromal tumors (GISTs) are caused by gain-of-function mutations in the Kit receptor tyrosine kinase. Most primary GIST...
JournalClub: mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate
The mechanistic target of rapamycin complex 1 (mTORC1) regulates cell growth in response to nutrients. Marat et al. found that the lipid...
Journal Club: ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Gli
Highlights GSCs can be classified into two subgroups based on ASCL1 expression ASCL1 is required for GSCs to undergo neuronal lineage...
Welcome Audrey Gayraud
Welcome to Audrey Gayraud, Master Student, Universite Nantes, for her training in the lab. She will work on linear ubiquitin assembly...
Journal Club: Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Fun
BRD4 represses a program of autophagy and lysosome genes independently of MiT/TFE BRD4 de-repression promotes certain types of autophagy,...
Journal Club: MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and
Highlights MLKL facilitates endosomal trafficking independently of induction of necroptosis RIPK3 boosts release of...
Research Highlight: Glioblastoma stem-like cells secrete the pro-angiogenic VEGF-A factor in extrace
Our new study on #extracellularvesicle in #glioblastoma published in Journal of Extracellular Vesicles! ABSTRACT Glioblastoma multiforme...
Journal Club: Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells
#Vasioukhin #cellpolarity #cellcelladhesion #neuralstemcell #Dev_Cel LLGL1 loss in embryonic neural stem cells (ENSCs) results in...