Signaling in Oncogenesis, Angiogenesis, and Permeability

Cell There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic...

#ResearchSquare #Preprints Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR releases intracellular...

Nature volume 585, pages283–287(2020) Abstract The risk of cancer and associated mortality increases substantially in humans from the age...

Highlights Tissue acidification is a major chemical hallmark of the tumor microenvironment PRL-expressing cells can grow in an acidic...

Breast cancer brain metastases (BCBM) have a 5-20 year latency and account for 30% of mortality; however, mechanisms governing adaptation...

Cancer cells, including melanoma cells, often metastasize regionally through the lymphatic system before metastasizing systemically...

https://www-nature-com.proxy.insermbiblio.inist.fr/articles/s41388-020-01420-x?fbclid=IwAR0LnEeJSj2pWuCpEzzrlD3Fcp5hk9o_UrqQZiwslHA_kQn1G...

Here is our perspective in Cell Cycle on Lysosomes in Glioblastoma.

Highlights • Non-cleavable caspase-8 (caspase-8 DA) causes inflammation, blocked by necroptosis • Inflammation in Casp8DA/DAMlkl−/− mice...