Journal Club: Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Ne
Highlights • Non-cleavable caspase-8 (caspase-8 DA) causes inflammation, blocked by necroptosis • Inflammation in Casp8DA/DAMlkl−/− mice...
Journal Club: Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative St
Highlights A high level of DGAT1 is associated with poor survival in individuals with GBM DGAT1 prevents lipotoxicity in GBM by promoting...
Journal Club: Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade S
Highlights Soluble human ACE2 can inhibit SARS-CoV-2 infections SARS-CoV-2 can directly infect human blood vessel and kidney organoids...
Journal Club: Transfer of microRNA via Macrophage-Derived Extracellular Vesicles Promotes Proneural-
Proneural-to-mesenchymal transition (PMT) is a common process in glioblastoma (GBM)49 progression that leads to increased radiotherapy...
Journal Club: TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9
Abstract ________________________________________ Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and...
Journal Club: LUBAC accelerates B-cell lymphomagenesis by conferring B cells resistance to genotoxic
Key Points LUBAC accelerates B-cell lymphomagenesis through protection of DNA damage-induced apoptosis, thereby promoting AID-mediated...
Journal Club: Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 ax
Abstract __________________________________________________________________________________________________________ Continuous cancer...
Journal Club: The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination o
Abstract The linear ubiquitin chain assembly complex (LUBAC), which consists of HOIP, SHARPIN and HOIL-1L, promotes NF-κB activation and...
