Journal Club: Wnt-mediated endothelial transformation into mesenchymal stem cell–like cells induces
Endothelial transformation in glioblastoma Glioblastoma (GBM) is one of the most aggressive brain tumors. GBM is characterized by...
Journal Club: Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage
ABSTRACT Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage that is the most common joint disease worldwide....
Journal Club: Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Def
Abstract Caspases regulate cell death, immune responses, and homeostasis. Caspase-6 is categorized as an executioner caspase but shows...
Journal Club: Gasdermin E suppresses tumour growth by activating anti-tumour immunity
Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1....
Journal Club: Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network
Highlights NPSC differentiation alters proteostasis strategies by rewiring chaperone network High TRiC/CCT in NSPCs promotes proteome...
Journal Club: Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas
KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic response that promotes hypovascularity,...