Journal Club: Gasdermin E suppresses tumour growth by activating anti-tumour immunity
Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1....
Journal Club: Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network
Highlights NPSC differentiation alters proteostasis strategies by rewiring chaperone network High TRiC/CCT in NSPCs promotes proteome...
Journal Club: Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas
KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic response that promotes hypovascularity,...
Journal Club: LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in gr
The Hippo and mammalian target of rapamycin complex 1 (mTORC1) pathways are the two predominant growth-control pathways that dictate...
Journal Club: An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
Liver disease defect identified The energy sensor adenosine monophosphate–activated protein kinase (AMPK) is implicated in liver damage...
Journal Club: Metabolites released from apoptotic cells act as tissue messengers
Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover in the body1, and regulates inflammation, cell...
Journal Club: Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis
Highlights ZIKV preferentially infects glioblastoma stem cells (GSCs) rather than neural precursor cells ZIKV kills SOX2 + cells from a...
Highlight: Prix Jeune Talent France-Chine pour Nicolas
Nicolas has received today Prix Jeune Talent France-Chine from Pôle Enseignement Supérieur, Recherche et Innovation Ambassade de France...